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norskBlar i forfatter "Johnsen, Peter Holger"
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Colonic distribution of FMT by different enema procedures compared to colonoscopy – proof of concept study using contrast fluid
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-23)Background Fecal microbiota transplantation (FMT) has become an important treatment method in recurrent Clostridioides difficile infections and is under investigation as a treatment for several other diseases. FMT’s mechanism of action is assumed to be through alterations of the colon microbiota. FMT can be delivered by several methods, but few studies have directly compared how FMT is distributed ... -
The effect of faecal microbiota transplantation in irritabel bowel syndrom. A double blind, randomized placebo controlled single centre study
(Doctoral thesis; Doktorgradsavhandling, 2020-04-17)Irritable bowel syndrome (IBS) is common disorder of the lower gastro intestinal tract associated with a poor quality of life. Revealing the interplay between the microbiota and the host has lead to a better understanding of IBS. A disturbance in the bidirectional communication in the microbiota-gut-brain axis is suggested to be involved in the pathophysiology of IBS. The microbiota in this context ... -
The effect of fecal microbiota transplantation on IBS related quality of life and fatigue in moderate to severe non-constipated irritable bowel: Secondary endpoints of a double blind, randomized, placebo-controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-23)<i>Background</i> - Severity in irritable bowel syndrome (IBS) is associated to impaired quality of life and fatigue. Fecal microbiota transplantation (FMT) induces significant relief in gastro-intestinal related complaints. The objective was to evaluate the effect of FMT on the secondary endpoints: IBS-related quality of life and fatigue in patients with non-constipated IBS.<p><p> <i>Method</i> ... -
Effects of fecal microbiota transplantation in subjects with irritable bowel syndrome are mirrored by changes in gut microbiome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-29)Irritable bowel syndrome (IBS) is a common disorder of the lower gastrointestinal tract. The pathophysiology is far from settled, but a gut microbial dysbiosis is hypothesized to be a contributing factor. We earlier published a randomized double-blind placebo-controlled clinical trial on fecal microbiota transplantation (FMT) for IBS – the REFIT trial. The present data set describes the engraftment ... -
Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)Introduction - Obesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve several obesity comorbidities. Options are conservative treatment such as lifestyle changes, bariatric surgery or medications. Conservative treatment has a low success rate, and ... -
Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)Introduction - Obesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve several obesity comorbidities. Options are conservative treatment such as lifestyle changes, bariatric surgery or medications. Conservative treatment has a low success rate, and ...
